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oncology anemia focal hemolytic localized disorders enlarged extravascular hodgkins lymphomas lymphoproliferative management mcv monoclonal nonhodgkin paraproteinemias pathophysiology spleen splenomegaly
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... Diagnosis Algorithm ... #LAD #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... , CLL, lymphoma, ... #Causes #differential ... #diagnosis #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Diagnosis Algorithm ... #LAD #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Lymphadenopathy ... Diagnosis Algorithm ... #LAD #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Diagnosis Algorithm ... Malignant • Lymphoma ... Serum Sickness Hemolytic ... #Diagnosis #Algorithm ... #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... IVIG infusion Intravascular ... #Diagnosis #causes ... #classification ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Diagnosis Algorithm ... • Bleeding • Hemolysis ... #Anemia #MCV #Classification ... Diagnosis #Algorithm ... #Causes #Hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Diagnosis Algorithm ... (NHL) ~60% - lymphadenopathy ... more diffuse, can ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Presentation: • Lymphadenopathy ... nodosum • Immune hemolytic ... Immunohistochemical studies (to differentiate ... #diagnosis #classification ... #hematology #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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