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diagnosis differential hematology anemia causes mcv atlas classification fe ferritin key macrocytic microcytic morphology normocytic pancytopenia platelets rbc testing thrombocytosis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Bleed • Hemolysis ... Microangiopathic Hemolytic ... Hypothyroid • Pregnancy ... • Early Iron ... Deficiency #
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... extravascular) hemolysis ... athletic training, Pulmonary ... intake: Anorexia, Pregnancy ... #ferritin #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #workup #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... inflammation) • Iron ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... #Anemia #MCV #Algorithm
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... Differential Diagnosis Algorithm ... Intravascular hemolysis ... athletic training, Pulmonary ... , Adolescence, Pregnancy
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
• Microcytic - Iron-deficiency ... spherocytosis, Hemolytic ... , Thalassemia, Iron-deficiency ... , Pulmonary emboli ... Schistocytes - Hemolytic
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Differential Diagnosis Algorithm ... /uL Initial Workup ... LDH, ESR, CRP, iron ... ↑ Destruction (hemolysis ... #hematology #workup
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... Volume (<80 fL) • Iron ... • Bleeding • Hemolysis ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
acute blood loss, hemolysis ... erythropoietin (EPO), iron ... substrate (e.g. iron ... #Diagnosis #Workup ... #Hematology #Microcytic
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Differential #Diagnosis #Algorithm
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