19 results
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... microangiopathies (TMA) - TTP ... organ or stem cell ... anemia" • HELLP ... #hematology #hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... coagulation (DIC) - HELLP ... thrombocytopenic purpura (TTP ... ) (e.g. lupus, CLL ... #hematology #anemia
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
/HUS, HELLP Syndrome ... the critically ill ... (Hemolysis, Elevated ... AFLP #obstetrics #hematology ... #diagnosis #table
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... TTP/HUS indicates ... uremic syndrome ... thrombocytopenia, Hematology ... 2012, p 193 #Diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
- Differential Diagnosis ... • SLE • CLL ... Non-lmmune: • HELLP ... SyndromeTTP ... Algorithm #Causes #Hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... (Hemolysis, Elevated ... of child 3) TTP ... Obstetrics #OBGyn #Hematology ... #Table
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Fragmentation - MAHA: TTP ... , HUS, DIC, HELLP ... Drug-associated, PCH, Evans Syndrome ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Consider sickle cell ... thrombocytopenia - DIC, TTP ... , HELLP, HUS, aHUS ... #Algorithm #workup ... #hematology #testing
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Diagnosis: • ... microglobulin Treatment ... #workup #oncology ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... Rebound effect from treatment ... #Algorithm #hematology