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Hemolytic Anemia - Hemolysis Diagnostic Workup

Infographic by: Howard Ong

#Hemolysis #Hemolytic #Anemia #Algorithm #MAHA #TTP #Diagnosis #Workup
- Hemolysis Diagnostic ... Workup Infographic ... Algorithm #MAHA #TTP ... #Diagnosis #Workup ... #Hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... microangiopathies (TMA) - TTP ... syndrome (ST-HUS ... #differential #diagnosis ... #hematology #hemolysis
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
Algorithm for workup ... TTP/HUS indicates ... uremic syndrome ... thrombocytopenia, Hematology ... 2012, p 193 #Diagnosis
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
and Pregnancy - TTP ... defects. 1) HELLP (Hemolysis ... Thrombocytopenia #TTPHUS ... AFLP #obstetrics #hematology ... #diagnosis #table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) - HELLP syndrome ... thrombocytopenic purpura (TTP ... syndrome (HUS) ... #hematology #anemia
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... defects. 1) HELLP (Hemolysis ... of child 3) TTP ... Obstetrics #OBGyn #Hematology ... #Table
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Microangiopathy - TTP ... distinction has HUGE treatment ... and first-line treatment ... thrombocytopenia #Comparison #Diagnosis ... #Table #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... Rebound effect from treatment ... #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... thrombocytopenia - DIC, TTP ... #Differential #Diagnosis ... #Algorithm #workup ... #hematology #testing
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Fragmentation - MAHA: TTP ... Drug-associated, PCH, Evans Syndrome ... #hematology