68 results
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... APLS:PLT ↓ HEMATOLOGIC ... MAHA: TTP, HUS, DIC ... Diagnosis #clots #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Causes include : ... Pre-analytical cause ... Fll, FV, FVII, FIX ... aPTT #Prolonged #Causes ... #differential #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disorders, or other causes ... • Secondary Causes ... marrow disease - DIC ... Differential #Diagnosis #hematology ... #rheumatology #
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
require urgent nephrology ... e.g NSAlDs) 3) FIX ... are caused by prerenal ... CONSIDER INTRINSIC CAUSES ... workup #diagnosis #nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... Negative urine dip ... Positive urine dip ... #Proteinuria #Nephrology ... Diagnosis #Algorithm #Causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... • TTP/HUS • DIC ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Fll, FV, FVII, FIX ... aPTT #Prolonged #Causes ... #differential #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Anemia Intrinsic Causes ... elliptocytosis Extrinsic Causes ... Intravascular Causes ... MAHA: TTP, HUS, DIC ... classification #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
helmet cells DDX ... MAHA: TTP/HUS > DIC ... Treat primary cause ... Coagulation #diagnosis #causes ... treatment #management #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... • MAHA (TTP, DIC ... Diagnosis #Algorithm #Causes ... #Hematology