14 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Microangiopathy - TTP VS HUS ... HUGE treatment ... #thrombocytopenia ... Comparison #Diagnosis #Table ... #Hematology
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Differential Diagnosis Table ... • Thrombotic Thrombocytopenic ... HUS (aHUS) ... Metabolism-mediated TMA - Coagulation-mediated ... Microangiopathy #TMA #hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... Pregnancy - TTP/HUS ... , HELLP Syndrome ... AFLP #obstetrics #hematology ... #diagnosis #table
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • ... Heart Valve) #Thrombocytopenia ... Algorithm #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disease - DIC/TTP/HUS ... Kasabach-Merritt syndrome ... : • DIC, TTP/HUS ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... Pregnancy Three syndromes ... presents with coagulation ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... ) - HELLP syndrome ... microangiopathy: Thrombotic thrombocytopenic ... (HUS) • Other ... differential #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
DDX: • TMA’s (HUS ... - MAHA: TTP/HUS ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... NSAIDs, quinine, etc ... Microangiopathy: DIC, TTP, HUS ... antiphospholipid syndrome ... Diagnosis #Framework #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Infection (eg ... leukopenia, anemia, and thrombocytopenia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology