22 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Hemolytic Anemia (AIHA ... ) - Differential ... Cold Agglutinin Disease ... #Differential # ... Diagnosis #Table #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Autoimmune: Warm AIHA ... Drug-associated, PCH ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis - Differential ... • PCH ... Prosthetic heart valves ... Extravascular #Differential ... Algorithm #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Hemolytic Anemia (AIHA ... Treatment Warm AIHA ... esp if severe disease ... , Splenectomy, MMF ... Treatment #management #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... Causes: • Liver disease ... Hypersplenism • AIHA ... Diagnosis #causes #classification ... #hematology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Chain deposition disease ... atheroembolic, AIHA ... Mnemonic #diagnosis #differential ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Renal Disease, Liver ... #Anemia #MCV #Classification ... #Differential # ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
- Autoimmune (AIHA ... - Autoimmune (AIHA ... cold agglutin disease ... Extravascular #Causes #differential ... #diagnosis #hematology
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm

Elevated Hemoglobin:
 • Males: Hb > 16.5 g/dL/HCT ≥ 49%
 •
- Polycythemia Differential ... Cardiac/pulmonary disease ... , HCC, uterine fibroids ... Polycythemia #Vera #PV #Differential ... Diagnosis #Algorithm #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Approach to Anemia - Differential ... Anemia of Chronic Disease ... Non-lmmune #Anemia #Classification ... #Approach #Differential ... Algorithm #Causes #Hematology