29 results
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
(warfarin) • Factor ... inhibitor • Liver ... elevated in: • DIC ... Thromboplastin #laboratory ... #hematology #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Consumption of Clotting Factors ... protein C and S Pathophysiology ... venipuncture sites Laboratory ... • Severe Liver ... treatment #management #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Deficiency of Factor ... ) • Advanced Liver ... Post-partum • Acute DIC ... Summary #table #comparison ... #diagnosis #hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
either a clotting factor ... inhibitor of normal factor ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Cholangitis #pathophysiology ... #pbc #psc #hepatology ... #comparison
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation (DIC ... of coagulation factors ... of thrombin and factor ... Scoring #diagnosis #hematology ... #laboratory
Approach to a Positive (+) Rheumatoid Factor (RF)
(+) RF does not always = RA
Rheumatic disorders:
 •
(+) Rheumatoid Factor ... Inflammatory disorders of Liver ... #Rheumatoid #Factor ... #RF #rheumatology ... #laboratory #differential
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
could be multiple factors ... Decreased factor ... • Reduced liver ... intravascularcoagulation (DIC ... #differential #hematology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... production of clotting factors ... As a result of DIC ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
and Bleeding in Liver ... von Willebrand factor ... Generation • Incr Factor ... Clot #Cirrhosis #Pathophysiology ... #Hepatology #Liver