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diagnosis hematology differential oncology management chronic classification lymphocytic mds myelodysplastic thrombocytosis workup basophilia basophils blood elevatedmcv endocrinology enlarged gap globulin
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Differential Diagnosis Algorithm ... Pelger-Huet, Macrocytic anemia ... or λ), Smudge Cells ... #hematology #Markers ... Differential #Diagnosis #Algorithm
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... -> AML: Blast crises ... - infiltrates (anemia ... ) CLL Symptoms: ... #Hematology #Oncology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... Differential Diagnosis Algorithm ... • Metabolic disorders ... pancytopenia, blast cells ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
or basket cells ... lymphoproliferative disorders ... • Neutropenia, anemia ... leukemia #CLL ... workup #oncology #hematology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Differential Diagnosis Algorithm ... Lymphoproliferative Disorders ... Anemia - Others ... Differential #Diagnosis #Algorithm ... endocrinology #causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... ITP • SLE • CLL ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Chronic Myelogenous Leukemia ... • Rheumatic disorders ... Iron deficiency anemia ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Chronic inflammatory disorders ... Chronic myeloid leukemia ... (CML) - Dr.
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
similarly to mast cells ... Myeloproliferative Disorders ... Chickenpox Other Causes ... Differential #Diagnosis #causes ... #hematology #basophils
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Differential Diagnosis Algorithm ... • Lymphoma • Leukemia ... Myeloproliferative disorders ... Disease • Sickle Cell ... #Causes #Hematology
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