21 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... Bloodman #Pregnancy #Thrombocytopenia
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... presents with coagulation ... defects. 1) HELLP ... child * Severe cases ... Pregnancy #TTPHUS #HELLP
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... purpura (TTP) • HELLP ... intravascular coagulation ... (DIC) • Anti-coagulation ... Diagnosis #Algorithm #Causes
Algorithm for the outpatient management of thrombocytopenia. 
(DIC = disseminated intravascular coagulation; EDTA = ethylenediaminetetraacetic acid;
management of thrombocytopenia ... intravascular coagulation ... ethylenediaminetetraacetic acid; HELLP ... ; ITP = immune thrombocytopenic ... TTP = thrombotic thrombocytopenic
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Diagnosis Algorithm Thrombocytopenia ... • Vasculitis Coagulation ... deficiencies Coagulation ... Diagnosis #Algorithm #Causes
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... DITMA) - MAHA + Thrombocytopenia ... coagulopathy - Thrombocytopenia ... Treat primary cause ... #diagnosis #causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Non-lmmune: • HELLP ... Heart Valve) #Thrombocytopenia ... Diagnosis #Algorithm #Causes
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... inflammation • Thrombocytopenia ... Platelet defects • Coagulation ... : - Thrombocytopenia ... Kasabach-Merritt syndrome Coagulation
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... (DIC) - HELLP ... microangiopathy: Thrombotic thrombocytopenic ... Extravascular #Causes
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... → Palpable • Thrombocytopenia ... HIT, ITP/HUS), Coagulation ... nonpalpable #palpable #Causes