15 results
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... #Pregnancy #TTPHUS
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... #TTPHUS #HELLP
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Diagnosis Algorithm Thrombocytopenia ... • Vasculitis Coagulation ... deficiencies Coagulation ... Diagnosis #Algorithm #Causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... • Idiopathic thrombocytopenic ... intravascular coagulation ... (DIC) • Anti-coagulation ... Diagnosis #Algorithm #Causes
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... DITMA) - MAHA + Thrombocytopenia ... coagulopathy - Thrombocytopenia ... Treat primary cause ... #diagnosis #causes
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... inflammation • Thrombocytopenia ... Platelet defects • Coagulation ... : - Thrombocytopenia ... Kasabach-Merritt syndrome Coagulation
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... → Palpable • Thrombocytopenia ... HIT, ITP/HUS), Coagulation ... nonpalpable #palpable #Causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... microangiopathy: Thrombotic thrombocytopenic ... Extravascular #Causes
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... triad of MAHA + thrombocytopenia ... metabolism and coagulation-mediated
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
individuals with thrombocytopenia ... ecchymosis) is caused ... are typical of coagulation ... Measurement of coagulation ... Bruise #ecchymosis #thrombocytopenia