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hematology causes hemolytic oncology activation autoantibodies bleeding erythematosus extravascular glomerulonephritis hemolysis intravascular leukemoid leukocytosis macrophage management mas mds mimickers monoclonal
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
of Bleeding / Bruising ... - Differential ... Diagnosis Algorithm ... Thrombocytopenia ... Diagnosis #Algorithm
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Diagnosis Algorithm ... Symptoms: B-symptoms, bruising ... hepatomegaly • Labs: anemia ... #Diagnosis #Algorithm ... #hematology #WBC
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Diagnosis #Algorithm ... #Causes #Hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... (aPL) 30-45% Differential ... Diagnosis and Lupus ... #rheumatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Purpura or Easy Bruising ... SLE (systemic lupus ... Scurvy #Purpura #Bruising ... peds #pediatrics #diagnosis ... #differential #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Diagnosis Algorithm ... Schistocytes, thrombocytopenia ... Diagnosis #Algorithm
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(-) hemolytic anemia ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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