19 results
Lupus Nephritis Classification Algorithm

#Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Algorithm #Lupus ... Classification #Algorithm #diagnosis ... differential #types #rheumatology ... #nephrology #renal
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... Cryoglobulinemia Renal-centered ... , Type I cryo GN ... #Differential #Diagnosis ... #hematology #oncology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... #differential #diagnosis ... #algorithm #rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... to cold IgG • Lupus ... vascular beds-renal ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... Vasculitis 1 ... arterioles) MONOCLONAL ... arthritis • Renal ... #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... ANCA-Associated Vasculitis ... vasculitis - MPO ... #diagnosis #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... Polymerase Ill • ANCA Vasculitis ... Autoantibodies #Rheumatology ... #diagnosis #associations
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
pericarditis • Hematologic ... hemolysis • Renal ... Highly specific antibodies ... Erythematosus #diagnosis ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
rapidly progressing GN ... pulmonary and renal ... C-ANCA) pattern: antibodies ... • Urinalysis (Renal ... #rheumatology #
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Renal involvement ... cryoglobulinemia vasculitis ... TerrierBen #Renal ... #Management #Rheumatology ... Cryoglobulinemic #Nephrology