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diagnosis management algorithm anemia causes comparison liver oncology pathophysiology aflp blood ctchest obstetrics polycythemia pregnancy product pulmonary radiology radiologyassistant reactions
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Inflammatory: • IBD ... malignancy • Iron deficiency ... Thrombocytosis #Differential ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... → Refer to hematology ... Acute hemolysis, deficiency ... Thrombocytosis #Platelets #Differential ... Diagnosis #Algorithm #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... Anemia - Differential ... Tropical sprue, IBD ... #Anemia #Differential ... Algorithm #ferritin #hematology
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
- Polycythemia Differential ... Hb > 16.5 g/dL/HCT ... : Hb > 16 g/dL/HCT ... Polycythemia #Vera #PV #Differential ... Diagnosis #Algorithm #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
= (Retic %) x (Hct ... deficiencies: Iron deficiency ... cell anemia, G6PD deficiency ... Production #Index #hematology ... #anemia #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... NAFLD • Others Mild ... • AIH • A1AT deficiency ... Others #LFTs #Hepatology ... #LiverEnzymes #Differential
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... contraceptives - HRT ... Ischemic Liver, IBD ... pathophysiology #hematology ... #differential #
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... with underlying mild ... folate deficiency ... #FolicAcid #differential ... #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... accumulation of clinical ... Assessment • Clinical ... Cellular immune deficiency ... PTLD), allogeneic HSCT
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... anemia, GATA2 deficiency ... , CTLA4 deficiency ... • Allogeneic HSCT ... Anemia #oncology #hematology
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