18 results
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Demyelinating syndromes ... ) Blood (75%): Anemia ... SLE #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Differential Diagnosis Algorithm ... effect following treatment ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Causes #Hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... autoantibodies #signs #symptoms ... #differential #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
of anemia or thrombocytopenia ... Constitutional symptoms ... marrow failure with anemia ... or thrombocytopenia ... Leukemia #oncology #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus erythematosus ... with leukopenia, anemia ... , and thrombocytopenia ... Treatment: • Corticosteroids ... #Rheumatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... infections/fevers • Thrombocytopenia ... Treatment: ... • Improve the symptoms ... #oncology #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... anti-synthetase syndrome ... Around half of anti-SRP ... after 2 years of treatment ... Myositis #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Shrinking lung syndrome ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... #Diagnosis #Rheumatology