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diagnosis hematology differential hemolysis aiha causes extravascular intravascular workup agglutinin anemias comparison disease management mcv refeeding symptoms syndrome testing treatment
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Signs of anemia ... and hemolysis: ... Immune-mediated Hemolysis ... : • Autoimmune ... Nonimmune-mediated Hemolysis
Anemia - Hemolysis Diagnostic Algorithm Autoimmune hemolytic anemia Microangiopathic hemolytic anemia Probable thalassemia Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Autoimmune hemolytic ... hemolytic anemia ... EricsMedicalLectures/ #Hemolysis ... #Anemia #Algorithm
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Warm vs Cold Autoimmune ... Hemolytic Anemia ... Hemolytic Anemia ... Autoimmune Hemolytic ... Mostly transient hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... anemia): ... Extravascular Hemolysis ... EricsMedicalLectures/ #Hemolysis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... anemia • ... malformations #Hemolysis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... - Warm vs Cold ... #Hemolytic #Anemia ... #Pathophysiology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Immune mediated hemolysis ... idiopathic, malignancy, autoimmune ... #Diagnosis #Algorithm
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... > 10, no more hemolysis ... azathioprine Cold ... #Hemolytic #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold ... elliptocytosis, autoimmune ... hemolysis) ARUPConsult
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... anemia • Cold ... • Compensated hemolysis ... CLL (older) • Autoimmune ... intravascular hemolysis
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