16 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
of anemia and hemolysis ... Immune-mediated Hemolysis ... : • Autoimmune ... Nonimmune-mediated Hemolysis ... #Anemias #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Extravascular Hemolysis ... EricsMedicalLectures/ #Hemolysis ... #differential #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... anemia • ... malformations #Hemolysis
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Hemolytic Anemia ... reticulocytes • Hemolysis ... • Blood smear: Differential ... 2) LOOK FOR a cause ... #Hemolytic #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Immune mediated hemolysis ... idiopathic, malignancy, autoimmune ... #Anemia #Differential ... Diagnosis #Algorithm #causes
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral infection, autoimmune ... anemiaCold ... • Compensated hemolysis ... younger pts) Differential ... intravascular hemolysis
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... elliptocytosis, autoimmune ... hemolysis) ARUPConsult ... #Anemia #Differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... : Warm AIHA, Cold ... Defects: Sickle cell anemia ... Urobilinogen #Hemolysis
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... - Differential ... malignancies • Anemia ... iron deficiency, hemolysis ... disorders (e.g. autoimmune
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
Hemoptysis - Differential ... carcinoid, Mets), COPD ... Rheumatologic / Autoimmune ... AVM, Thoracic aortic ... Diagnosis #pulmonary #causes