32 results
diagnosis differential rheumatology causes hematology management classification systemic vasculitis allergy dermatology disorders erythematosus hus lupus nephrology proteinuria pulmonary symptoms acute
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... angioedema A - Atypical ... antiphospholipid syndrome ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal Syndromes ... anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... Vasculitis - Normal Complement ... - MAHA: HUS, atypical
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Uremic Syndrome ... autoimmune like SLE ... It is complement ... with Eculizumab (complement ... @JustinMD19 #Atypical
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
hemolytic-uremic syndrome ... (ST-HUS) - Complement-mediated ... formerly known as atypical ... anemia" • HELLP syndrome
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Anti-Ribo-P 5-15% If SLE ... overlap syndromes ... higly specific for SLE ... patients with typical ... SLE.
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... • Cogan Syndrome ... against MPO • Complement ... vasculitis, and SLE
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
is due to TTP, compliment-mediated ... TTP (atypical HUS ... catastrophic APS, SRC, SLE
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Differential Diagnosis Algorithm ... Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... Differential #Diagnosis #Algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... diseases: - 10% SLE ... 20% Sjögren's syndrome ... • Low serum C4 complement ... erythematosus (SLE
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Differential Diagnosis Algorithm ... hypereosinophilic syndrome ... Hyper-lgE (Job) syndrome ... , Sarcoidosis, SLE ... Differential #Diagnosis #Algorithm
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