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diagnosis differential rheumatology hematology vasculitis thrombocytopenia classification hus management algorithm atypical c3 c4 causes champs cryoglobulinemia cryoglobulins dermatology erythematosus framework
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... antiphospholipid syndrome ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Uremic Syndrome ... autoimmune like SLE ... It is complement ... with Eculizumab (complement ... #Uremic #Syndrome
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... Vasculitis - Normal Complement ... hypertension - MAHA: HUS ... , atypical HUS,
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... Levels - C3, C4 • SLE ... • Infection eg SBE ... C3 ↓ C4 → • HUS ... ThePeanutKidney #Complement
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
hemolytic-uremic syndrome ... (ST-HUS) - ... Complement-mediated ... known as atypical HUS ... anemia" • HELLP syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... • Cogan Syndrome ... against MPO • Complement ... vasculitis, and SLE
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
is due to TTP, compliment-mediated ... TTP (atypical HUS ... ), Shiga-toxin HUS ... catastrophic APS, SRC, SLE ... diagnosis #ttp #hus
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS •
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
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