14 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... AntiCoagulation #Cascade ... #Pharmacology #Pathophysiology ... Mechanisms #DOAC #Hematology
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
numerals refer to coagulation ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade ... #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... • Vasculitis Coagulation ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... cascade is shown ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... Differential #Diagnosis #Algorithm ... #Causes #Hematology ... #coagulation #disorders
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
Cascade Traditional ... Initiation phase caused ... #Cascade #diagnosis ... #models #hematology ... #pathophysiology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... AFLP #obstetrics #hematology ... #diagnosis #table
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
hemorrhage, while under-coagulation ... #management #algorithm ... #medications #table ... decisionaid #cardiology #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... protein C and S Pathophysiology ... Treat primary cause ... #diagnosis #causes ... treatment #management #hematology