635 results
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Erythematosus (SLE ... system defects (i.e ... Interferon-a, IL ... -6, IL-10 #Systemic ... Erythematosus #SLE
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Erythematosus (SLE ... Erythematosus #SLE
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Spondyloarthropathies, SLE ... retinal exudates) - SLE ... nodules - RA, SLE ... disease - RA - SLE ... • Seizures - SLE
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... Associated with SLE-SSc-AlM ... higly specific for SLE ... patients with typical SLE
Approach to managing Glomerulonephritis (GN) in children. 

ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
cytoplasmic antibodies; SLE ... Glomerulonephritis #Algorithm
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
pattern: - SLE ... pattern: - SjS, SLE ... Speckled: - SLE ... conditions, SjS, SLE ... Golgi/polar: - SLE
Monoarthritis - Differential Diagnosis
Infection (Acute):
 - S. aureus (most common)
 - S. pneumonia
 - Salmonella (in
Gout- usually LE ... arthritis - SLE
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Non-specific; common in SLE ... RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Diffuse) Anti-Sm - SLE
Intravenous Lipid Emulsion (ILE) Therapy

ILE is a treatment for severe toxicity from local anesthetics. In addition,
Lipid Emulsion (ILE ... ) Therapy ILE ... Lipid #Emulsion #ILE
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
manifestations • Neonatal SLE ... dysmotility • MCTD (SLE ... • Specific for SLE ... Erythematosus #SLE