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Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Drugs: Direct or ... drugs (e.g. direct ... Prolonged #Causes #diagnosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Drugs a. ... Drugs a. ... drugs e.g. direct ... Prolonged #Causes #diagnosis ... #differential #hematology
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
Drugs associated ... Antimicrobials Drug-induced ... Tyrosine kinase inhibitors ... panitumumab) #Drugs ... #differential #diagnosis
Drugs Commonly Implicated as Triggers of Drug Induced Thrombocytopenia #Diagnosis #Hematology #Thrombocytopenia #Differential #DrugInduced #Medications
Drugs Commonly Implicated ... as Triggers of Drug ... Thrombocytopenia #Diagnosis ... #Hematology #Thrombocytopenia
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Direct renin inhibitor ... Angiotensin-converting enzyme (ACE) inhibitors ... • Calcineurin Inhibitors ... #differential #diagnosis
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
deficiency, or an inhibitor ... deficiencies and inhibitors ... Patient has a factor inhibitor ... Mixing #Study #diagnosis ... #hematology #laboratory
Drugs causing hyperkalemia • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly •
Drugs causing hyperkalemia ... Angiotensin-converting enzyme inhibitors ... Drospirenone #Drugs ... #differential #diagnosis
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
- Differential Diagnosis ... Hypercalcemia - Drug-Induced ... Antiuricosuric drugs ... • ACE inhibitors ... #Differential #Diagnosis
Urine Drug Screens - Common drugs that may cause false positive tests Amphetamines: Bupropion, Labetalol, Methylphenidate, Phenylephrine,
Urine Drug Screens ... - Common drugs ... Efavirenz, Proton pump inhibitors ... Laboratory #Toxicology #Diagnosis
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
NSAIDs, calcineurin inhibitors ... decongestants) • Any drug ... #Medications #Drugs ... #differential #diagnosis
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