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Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Drugs: Direct or ... drugs (e.g. direct ... Inhibitors: Non ... Causes #diagnosis #differential
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
Drugs associated ... Antimicrobials Drug-induced ... Tyrosine kinase inhibitors ... panitumumab) #Drugs ... #Medications #differential
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Drugs a. ... Direct Xa inhibitors ... Drugs a. ... drugs e.g. direct ... Causes #diagnosis #differential
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Direct renin inhibitor ... Angiotensin-converting enzyme (ACE) inhibitors ... • Calcineurin Inhibitors ... #hyperkalemia #differential
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... Hypercalcemia - Drug-Induced ... Antiuricosuric drugs ... • ACE inhibitors ... Hyperuricemia #Differential
Drugs causing hyperkalemia • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly •
Drugs causing hyperkalemia ... Angiotensin-converting enzyme inhibitors ... Drospirenone #Drugs ... medications #causes #differential
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
NSAIDs, calcineurin inhibitors ... decongestants) • Any drug ... #Medications #Drugs ... #pharmacology #differential
Common causes of Acute Kidney Injury AKI - Differential Diagnosis HEMODYNAMIC • Cardiac failure: Impaired forward flow,
Kidney Injury AKI - Differential ... e.g. calcineurin inhibitors ... systemic disease or drugs ... hypotension • Drugs ... #KidneyInjury #Differential
Causes of Hypomagnesemia Redistribution: - IV glucose - Correction of diabetic ketoacidosis - IV hyperalimentation - Refeeding
renal disease Drugs ... - Proton pump inhibitors ... - Calcineurin inhibitors ... Causes #diagnosis #differential ... #medications #drugs
Metabolic Acidosis with Anion Gap - KILU Mnemonic K - Ketoacidosis • DKA - With normal glucose, ask if
ask if on SGLT2 inhibitor ... ketoacidosis in SGLT2 inhibitors ... or leukemia or drug ... Acidosis #diagnosis #differential
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