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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... - Disseminated intravascular ... coagulation (DIC ... Hemolysis #Hemolytic #Intravascular ... #Causes #differential
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... • Vasculitis Coagulation ... • Disseminated Intravascular ... Coagulation ... Diagnosis #Algorithm #Causes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Coagulation (DIC ... Treat primary cause ... #Disseminated #Intravascular ... #causes #treatment
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... - Disseminated intravascular ... coagulation (DIC
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... • Disseminated intravascular ... coagulation (DIC ... ) • Anti-coagulation ... Diagnosis #Algorithm #Causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Disseminated intravascular ... coagulation (DIC ... aPTT #Prolonged #Causes
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... (disseminated intravascular ... coagulation) ... Purpura #Bruising #Causes
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
considered in all cases ... - Disseminated intravascular ... coagulation and ... other causes of
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... , disseminated intravascular ... coagulation, or ... discern these causes
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... and Intravascular ... PK deficiency Intravascular ... #Hemolysis #Intravascular ... Diagnosis #Algorithm #Causes
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