78 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... > 20x normal - Acute ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... Liver #Injury #hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Causes of Severe ... - Ichemic hepatitis ... hepatitis - Wilson disease ... #Causes #Differential ... #Hepatology #Diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... ischemia and/or ... cyclophosphamide • Ischemic ... #rheumatology #
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... : Acute blood loss ... Vasculitides, IBD, Celiac disease ... Diagnosis #Algorithm #hematology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
• NAFLD • Cirrhosis ... Hepatopathy • Acute ... liver injury) • Ischemic ... Differential #Diagnosis #hepatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Causes of Thrombocytosis ... Infectious: • Acute ... disorders • Celiac disease ... Diagnosis #Algorithm #Causes ... #Hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Drugs/Toxins • Ischemia ... • Cholestatic disease ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Causes of Splenomegaly ... Congestive • Cirrhosis ... Spherocytosis • Acquired causes ... Diagnosis #Algorithm #Causes ... #Hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... translocation • Acute ... Colitis and Crohn’s Disease ... Irradiation • Cirrhosis ... #hematology #basophils
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Sickle Cell Disease ... Pathophysiology of disease ... obstructing and reducing blood ... organs leading to ischemia ... Complications #Hematology