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differential causes algorithm transaminitis management nephrology aki laboratory rheumatology classification elevated elevation function hepatitis hepatocellular interpretation lactate product reactions tests
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... > 20x normal - Acute ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Hepatopathy • Acute ... injury) • Ischemic ... #hepatology #transaminitis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... - Ichemic hepatitis ... injury - Viral ... #Differential #Hepatology ... #Diagnosis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... skeletal muscle and kidney ... Transaminitis #diagnosis ... #differential #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
(LFTs) - Normal ... brain, heart, blood ... hepatocellular injury ... Interpretation #diagnosis ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Diagnosis Framework ... : Liver Injury ... • Vascular: Ischemic ... #Diagnosis #hepatology ... Transaminitis #LFTs
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... skeletal muscle, kidney ... #FunctionTest #LFTs ... Transaminitis #diagnosis ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... intestines, White blood ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Prerenal: • Due to true volume loss or decreased
Acute Kidney Injury ... effective arterial blood ... necrosis) • Ischemic ... #Kidney #Injury ... #nephrology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... disease, Hepatic ischaemia ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
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