16 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Exogenous (KCL ... MunerMohamed1 #hyperkalemia ... differential #diagnosis #pathophysiology ... #pharmacology #
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Aldosterone Release: ACE ... happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology #
Iron Deficiency in Congestive Heart Failure (CHF)

Iron deficiency (ID) in heart failure is a common comorbidity
Heart Failure (CHF ... depot iron] Treatment ... Heart #Failure #CHF ... #pharmacology # ... pathophysiology
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
INDICATION: Treatment ... of Hyperkalemia ... patients with CKD, HF ... ACE inhibitors, ... #Pharmacology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Na delivery): CHF ... Stabilization Treatments ... Ca-gluconate or 1g CaCl ... Redistribution Treatments
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Heart Failure Pathophysiology ... functional ID) Treatment ... composite endpoint of all-cause ... iron #deficiency #CHF
Heart Failure (HFrEF) Treatment - GDMT for stage C 

For patients with Heart Failure with REDUCED
Failure (HFrEF) Treatment ... recommended by the ACC ... /ambcarerx #CHF ... #HFrEF #Pharmacology ... #Management #Treatment
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... organ damage • Treatment ... Lysis Syndrome: • Pathophysiology ... hydration - Hyperkalemia
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Pathophysiology ... complete paralysis of all ... - NORMAL CSF ... Treatment: • Plasmapheresis ... diagnosis #management #treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... Triggers: ATRA treatment ... Pathophysiology ... sepsis), PE, DAH, CHF ... Renal Failure Treatment