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differential erythematosus systemic algorithm arthritis classification druginduced summary syndrome treatment vasculitis activation ana anca antibodies antineutrophil antinuclear antiphospholipid apls approach
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... determined by Positive test ... Direct Coombs’ test ... #Rheumatology # ... SLE #Lupus #Erythematosus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... • Immunologic Workup ... #table #rheumatology ... #diagnosis #management
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... if < 200ng/mL Best ... #rheumatology # ... pharmacology #levels #lupus ... #management
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... , ANA (e.g., SLE ... #Causes #Workup ... #hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Initial screening test ... #Summary #diagnosis ... #rheumatology # ... management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... (to support a diagnosis ... #diagnosis #testing ... #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear Antibody ... ) • Systemic lupus ... in drug-induced SLE ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... Erythematosus #SLE ... CNS #neurology #rheumatology ... #management #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... Liver function tests ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
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