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management associations autoantibodies comparison differential diseases ana anca antibody antineutrophil antinuclear arterial cold disorders druginduced embolism hemeonc hemophagocytic hlh lupus
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... antibodies) • ... Anti-cardiolipin (aCl ... Autoantibodies #Rheumatology ... #table
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... anti-phospholipid antibodies ... not required in all ... #Differential #Diagnosis ... #hematology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... scleroderma) - Anti-Scl ... seen in 30—70% of cases ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
syndrome Anti-Scl ... Associations #diseases #diagnosis ... #table #rheumatology ... #antibodies
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
decades of life Causes ... doi: 10.1111/all ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... Antiphospholipid antibodies ... considered in all ... coagulation and other causes ... pathophysiology #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
thiazidic, PPI, ACE ... Discontinuation of causal ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Males • Affects all ... /EGPA • RA Diagnosis ... Anti-Matrilin-1 Ab ○ Antibodies ... Polychondritis #rheumatology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
is a critical diagnostic ... hyperinflammatory syndrome caused ... • In all patients ... inhibitors, anti-IFN-γ antibodies ... #Management #Hematology
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