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diagnosis syndrome oncology treatment algorithm rheumatology vasculitis leukemia neurology pulmonary workup arteritis bowel chronic classification cll dermatology disorders gastroenterology giantcell
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... predominant immature cells
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... RBCs - Sickle Cells ... , Target Cells ... #Hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophilia, 500-1,500 cells ... Hypereosinophilia, >1,500 cells ... organ-specific signs ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Oxyhemoglobin Dissociation Curve Left Shift - decreased unloading of O2 at tissue level (i.e. increased
stored red blood cells ... - Sickle cell anemia ... Dissociation #Curve #Pathophysiology ... #Right #Shift #Differential ... #Causes #Diagnosis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
yrs old; F>M Signs ... /Symptoms: - Fever ... - Normocytic Anemia ... - Giant cells ... Temporal #Arteritis #Pathophysiology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... Macrocytosis, Target Cells ... #elevatedMCV #Differential ... #Hematology
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Pathophysiology: ... germinative skin cells ... Causes: 1) Exfoliative ... Skin-homing T-cells ... Nikolsky #Algorithm #Differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... hematopoietic stem cells ... number of CD34+ cells ... number of CD34+ cells ... Number of CD34+ cells
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Characterized by red blood cells ... These cells can ... sequestration of sickle cells ... Crisis #Features #Signs ... #Symptoms
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... = funny-shaped cells ... old, ~10,000 new cases ... cytopenias (usually anemia ... #treatment #hematology
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