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EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria ... for Systemic Lupus ... Constitutional domain: Fever ... , Acute cutaneous ... pericarditis • Hematologic
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
- Systemic Lupus ... - ACUTE CUTANEOUS ... - ANA level above ... Anti-dsDNA antibody level ... #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... ALT ↑ bilirubin level ... Histopathologic criteria
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... • Acute disseminated ... • Systemic lupus ... #neurology #inflammatory ... #differential #
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Cough, Dyspnea, Fever ... Immune Complex: Systemic ... lupus erythematosus ... #differential # ... diagnosis #nephrology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis
 • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... Lemierre's syndrome ... Brucellosis, Q fever ... Malignancy: - Hematologic ... . autoimmune): Lupus
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... : Fever (50%), Depression ... Demyelinating syndromes ... Thrombocytopenia #Lupus ... symptoms #diagnosis #rheumatology
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
• Rheumatic Fever ... Lupus Erythematosus ... Sicca) Syndrome ... • Rheumatic Fever ... Acute Onset
Fever and Rash - Differential Diagnosis Framework
 • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... Differential Diagnosis ... Mono (EBV, CMV), Acute ... Medicine @SCVMCMed #Fever ... #Diagnosis #dermatology
Causes of Severe Aortic Regurgitation - Differential Diagnosis
Acute:
 • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Regurgitation - Differential ... Endocarditis, Rheumatic Fever ... Inflammatory: Lupus ... Ehlers-Danlos Syndrome ... Degenerative: Systemic