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diagnosis management lymphohistiocytosis criteria syndrome hemeonc rheumatology activation algorithm anemia aplastic apml causes classification differential differentiation emergencies enterocolitis hodgkins leukemia
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Hemophagocytic Lymphohistiocytosis ... Features: Fever, ... 8 criteria: • Fever ... #Hemophagocytic ... Lymphohistiocytosis #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... following: • Fever ... • Bicytopenia Treatment ... #Hemophagocytic ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... ALT ↑ bilirubin level ... Diagnosis #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Clinical: fever ... , ↓ Fibrinogen level ... Unknown cause Treatment ... #Hemophagocytic
Diagnostic criteria for Neutropenic Enterocolitis (NEC) Major Criteria: • Neutropenia (ANC <500 x 10^9 cells/L) • Bowel
30mm length) • Fever ... Criteria: • Abdominal ... distention • Abdominal ... Diagnosis #criteria #hematology ... #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009 At least three of the following: -
(HLH) Diagnostic ... following: - Fever ... @PulmCrit #HLH ... #Hemophagocytic ... Diagnosis #Criteria #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Characteristics: Persistent fever ... Persistent high fever ... Fever b. ... #HLH #Hemophagocytic ... Diagnosis #Management #Hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
characterized by fever ... Disorder: - Fever ... Symptoms: - Fever ... arthralgia) - Fever ... Syndrome #diagnosis #dermatology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... CT abdomen if abdominal ... or HSCT - CRS: fever ... therapy - Symptoms: fever
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Renal Failure Treatment ... diagnosis #management #hematology ... #oncology
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