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hematology differential treatment syndrome classification rheumatology thrombocytopenia aflp algorithm aplastic neurology obstetrics pregnancy reactions table workup blood cirrhosis disorders encephalopathy
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Definition • Pathophysiology ... #Aplastic #Anemia ... #diagnosis #oncology ... #hematololgy
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... - Differential Diagnosis ... #Differential #Diagnosis ... #Algorithm #Causes ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
and Management ... old, ~10,000 new cases ... cytopenias (usually anemia ... #Management #treatment ... #hematology #oncology
Oxyhemoglobin Dissociation Curve Left Shift - decreased unloading of O2 at tissue level (i.e. increased
of O2 at tissue level ... - Sickle cell anemia ... Dissociation #Curve #Pathophysiology ... #Differential #Causes ... #Diagnosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... - Differential Diagnosis ... #Differential #Diagnosis ... #Algorithm #Causes ... #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... : • Liver disease ... #Hemolytic #Anemia ... #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Diagnostic Framework ... for Anemia (Morphological ... : Alcohol use, Liver ... #differential #diagnosis ... #causes #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Diagnosis: • Pancytopenia ... if neutropenic fever ... #diagnosis #management ... #treatment #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... and petechiae Causes ... index < 2 • EPO Level ... #oncology #hematology ... #diagnosis #management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... ) Differential Diagnosis ... #Pregnancy #hepatology ... #management #pathophysiology
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