17 results
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... change disease • Hematologic ... malignancies Treatment ... Methotrexate • AIN ... #AKI #Cancer #Oncology
Medications causing Acute Kidney Injury (AKI)
Prerenal:
 • Dehydration: Diuretics
 • Altered intrarenal autoregulation: ACEIs / ARBs,
Acute Kidney Injury ... • Dehydration: Diuretics ... , tenofovir • AIN ... #Acute #Kidney ... #Drugs #pharmacology
Acute Kidney Injury (AKI) - Management Principles
Prerenal - Correct hemodynamic derangements:
 • If low preload →
Acute Kidney Injury ... (AKI) - Management ... high preload → Diuretics ... • AIN → Consider ... #Acute #Kidney
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Torsemide) • Acute ... hyperaldosteronism • Acute ... Tolvaptan) • Treatment ... #Nephrology #Pharmacology ... #Medications #Table
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... cardiorenal syndrome) • Liver ... nephritis (AIN) ... tract infection • Medications ... #Acute #Kidney
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... : • Common: fever ... Supportive Care: Diuresis ... diagnosis #management #hematology ... #oncology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... duration), Several medications ... non-essential drug/HDS treatments ... dechallenge • Acute ... Diagnosis #Algorithm #hepatology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
hepatitis, or acute ... Exclude other AKI ... HRS-Non-AKI (formerly ... Treatment Overview ... Hepatorenal #Syndrome #Hepatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
syndrome • Triggers: Diuretics ... - 80% have fever ... - ACS, AKI, ... acute limb ischemia ... diagnosis #management #hematology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
Metabolic syndrome • Medications ... (diuretics) ... swelling, significant pain ... • Discontinue diuretics ... #rheumatology