41 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... Massive tumor cell lysis ... cytotoxic therapy of ALL ... TumorLysis #syndrome #TLS
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... Syndrome (TLS) ... Tumor Cell Lysis ... TumorLysis #Syndrome #TLS
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... Abnormalities of TLS ... Laboratory TLS ... mg/dL Clinical TLS
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor Lysis ... leukapheresis - TLS ... rasburicase Tumor Lysis ... Pathophysiology: Lysis ... #Syndrome #TLS
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Treatment of Clinical TLS ... transfer • Tumor lysis ... MatthewHoMD #TLS ... #Tumor #Lysis #
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... but can also spontaneously ... Walid Malki, MD, MS ... wandering_er #Tumor #Lysis ... #Syndrome #TLS
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... Culprits: ALL, ... above #Tumor #Lysis ... #Syndrome #TLS
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... #Presentation #TLS
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
AKI) What to ask ... uric acid (rhabdo/TLS
Causes of Orthopnea - Differential Diagnosis Framework

 • Fear and Anxiety
 • Pleural Effusion
 • Ascites
- CNS lesion: ALS ... , MS, Polio -