110 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
, others (RNP, aPL ... Antiphospholipid Antibody Syndrome ... Anti-cardiolipin (aCl ... LAC) • Sjogren Syndrome ... Anti-centromere, Scl
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
- Na-K-2Cl cotransporter ... , K channel, Cl ... barrtin (recruits Cl ... Thiazide-sensitive Na—Cl ... alpha-Intercalated cell Cl
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
acid, Liddle's Syndrome ... R - Cushing's syndrome ... Normotensive: • UCl ... Post-hypercapnia • UCl ... , Gitelman's syndrome
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... , AML, NHL → AKI ... #TumorLysis #syndrome ... #TLS #Pathophysiology
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... transformation (CML ... hyperleukocytosis (AML ... Hyperviscosity #Syndrome
Irritable Bowel Syndrome (IBS) in Pregnancy
 - Pathophysiology
 - Pharmacotherapy
 - Nonpharmacological Treatment

Emory Gastroenterology and Hepatology
Irritable Bowel Syndrome ... in Pregnancy - Pathophysiology ... Nonpharmacological Treatment ... Irritable #Bowel #Syndrome
Autoimmune Gastritis - Pathophysiology

Anti-ParietaI Cell, CD4+ T Cells, Autoantibodies -> x Parietal Cells, x HCL, x
Autoimmune Gastritis - Pathophysiology ... Parietal Cells, x HCL ... Autoimmune #Gastritis #Pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... involvement CML ... ↓ LAP Score • CML ... develop leukostasis syndrome ... • Tumor lysis syndrome
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... differential #diagnosis #pathophysiology
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
in cardiorenal syndrome ... release • ↓ Cl ... #cardiorenal #syndrome ... #Mechanisms #pathophysiology