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diagnosis differential neurology treatment hematology lupus table algorithm antibodies associations autoantibodies classification cryoglobulinemia diseases erythematosus pharmacology renal systemic activation acutekidneyinjury
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... ANA (anti-nuclear ... LAC) • Sjogren Syndrome ... Ill • ANCA Vasculitis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-Scl-70 - Scleroderma ... La) - Sjogren's syndrome ... - Vasculitis, e.g ... - Vasculitis, e.g ... diagnosis #table #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Splenomegaly - CTD (SLE ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... Associated - SLE ... #rheumatology #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
in drug-induced SLE ... scleroderma) - Anti-Scl ... • Sjögren syndrome ... Vasculitis: • ... antibodies #diagnosis #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... arteritis, Cogan's Syndrome ... associated vasculitis ... erythematosus (SLE ... Differential #Diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... diseases: - 10% SLE ... erythematosus (SLE ... classification #rheumatology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... and probably < ... #Measurement #SLE ... #rheumatology # ... levels #lupus #management
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
cryoglobulinemia vasculitis ... Combined decr of C3 and ... Cryoglobulinemia #Vasculitis ... #Management #Rheumatology ... Cryoglobulinemic #Nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... • Cogan Syndrome ... LFT • ESR • ANA ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... Oral aphthae : SLE ... • Arthritis: SLE ... #diagnosis #management ... signs #symptoms #rheumatology
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