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hematology differential oncology disease management significance acute agglutinin aki algorithm amyloidosis anemia biopsy cancer capillary classification cold complications friction gap
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... (MGUS) - Differential ... Renal-centered (ie "MGRS ... #Gammopathy #Clinical ... #Significance #MGUS
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... , low-risk MGUS ... whom there are no clinical ... #monoclonal #gammopathy ... algorithm #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... hemangiomata, clubbing Clarkson ... ) MGRS: • Fibrillar ... #Differential #Diagnosis
Amyloidosis Diagnosis 1) Patient presentation • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved
Amyloidosis Diagnosis ... gammopathy of undetermined ... significance (MGUS ... neuropathy, atypical MGUS ... #cardiology
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Monoclonal Gammopathy ... ) MGRS • MGRS ... patients with MGUS ... Clinical Clues: ... #MGRS #Monoclonal
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... antibody - Early treatment ... rituximab (in clinical ... high-risk situations #MGUS ... #Monoclonal #Gammopathy
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
tubulopathy • Monoclonal ... gammopathy of renal ... significance (MGRS ... malignancies Treatment ... #Differential #Diagnosis
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Clarkson’s Disease ... Relapsing-remitting course +++ Clinical ... Monoclonal gammopathy ... Breillat #Clarksons ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... Monoclonal IgM ... gammopathy of undetermined ... significance (MGUS
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... : • MGUS • Multiple ... gammopathy, and ... changes (POEMS syndrome ... #differential #diagnosis
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