85 results
diagnosis hematology causes algorithm hemolytic treatment classification iron nutrition pulmonary rheumatology thrombocytosis autoimmune disease fever laboratory oncology acidosis aiha antibiotics
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential ... Anemias (AIHAs) ... Hypersplenism, Infection ... #Anemias #Differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... (e.g. cancer, infection ... , G6PD deficiency ... #differential #
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential ... DAT (-) → G6PD Deficiency ... Fevers, DAT (-) → Infection ... #Anemia #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... Mycoplasma pneumoniae infection ... G6PD deficiency) ... spherocytosis) • Infections ... Extravascular #Causes #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... • PK deficiency ... circulation - Infections ... anemia • ... Extravascular #Differential
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... fragmentation hemolysis ... • Severe B12 deficiency ... anemia" • HELLP ... #schistocytes #differential
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Macroangiopathic, Infections ... MCV #Algorithm #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... inclusions - If infection ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... 80 fL) • Iron Deficiency ... • Bleeding • Hemolysis ... Inflammation, Chronic Infection ... Classification #Differential
Iron Panel Interpretation Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation, ↓
Interpretation Iron deficiency ... , ↓ Ferritin Anemia ... Ferritin Iron deficiency ... Interpretation #deficiency ... #diagnosis #differential
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