12 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs ... of anemia and hemolysis ... Anemias (AHAs) ... #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... syndrome (ST-HUS ... known as atypical HUS ... anemia" • HELLP ... #hematology #hemolysis
Atypical HUS - Hemolytic Uremic Syndrome
Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Atypical HUS - Hemolytic ... still present with anemia ... renal, cardiac, pulmonary ... obtain ADAMTS13 activity ... #aHUS #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... DIC, TTP, HELLP, HUS ... , aHUS, mechanical ... #workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... uremic syndrome (HUS ... #differential #diagnosis ... #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential Diagnosis ... anemia • ... MAHA (TTP, DIC, HUS ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • MAHA: TTP, HUS ... #Diagnosis #causes ... classification #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... - MAHA: TTP, HUS ... Defects: Sickle cell anemia ... #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Iron Deficiency Anemia ... extravascular) hemolysis ... athletic training, Pulmonary ... diet, Alcoholism, Tea-toast ... Algorithm #ferritin #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disease - DIC/TTP/HUS ... - Hemolytic ... : • DIC, TTP/HUS ... #hematology #rheumatology ... #nonpalpable #dermatology