11 results
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Warm vs Cold Autoimmune ... Hemolytic Anemia ... BostonChiefs #Warm #Cold ... #Anemia #hematology ... #diagnosis #comparison
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis Table ... #Anemia #AIHA # ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) - HELLP syndrome ... uremic syndrome ... (e.g. primary cold ... #anemia
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Syndrome ... anemiaCold ... • Diagnostic Test ... Donath-Landsteiner test ... #anemia #hematology
Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing

SUMMARY:
 - RDW, FEP, serum iron,
Iron Deficiency Anemia ... non-invasive test ... marrow iron stain-"gold ... Laboratory #Testing #Comparison ... #Table #Fe
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Laboratory Tests
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
TTP/HUS, HELLP Syndrome ... defects. 1) HELLP (Hemolysis ... Elevated Liver tests ... #diagnosis #table ... #comparison
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
NEUROLOGIC - HEMOLYTIC ... ANEMIA - LEUKOPENIA ... reference range (or 2-fold ... Direct Coombs’ test ... #Rheumatology #
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
vertigo Diagnostic tests ... - Ice cube test ... , TempTest test ... Urticaria #diagnosis #rheumatology ... #comparison #table
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... defects. 1) HELLP (Hemolysis ... Elevated Liver tests ... #Diagnosis #Comparison ... #Table