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Anemia - Hemolysis Diagnostic Algorithm Autoimmune hemolytic anemia Microangiopathic hemolytic anemia Probable thalassemia Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Algorithm Autoimmune hemolytic ... anemia Microangiopathic ... hemolytic anemia ... hematology #diagnosis #differential
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... - Differential ... of anemia and hemolysis ... Macroangiopathic, Microangiopathic ... #Anemias #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Mechanical Trauma (Microangiopathic ... hemolytic anemia ... - Thrombotic microangiopathy ... Extravascular #Causes #differential
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... fragmentation hemolysis ... Drug-induced thrombotic microangiopathy ... • Mechanical hemolysis ... #schistocytes #differential
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential ... Schistocytes DAT(-) → Microangiopathic ... hemolytic anemia ... #Anemia #Differential
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Environment - Microangiopathic ... Sophia_Hayes_MD #Hemolytic ... #Anemia #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Bleed • Hemolysis ... Fragments • Microangiopathic ... Hemolytic Anemias ... Normocytic #Anemia #Differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... : • Hemolytic ... - Acquired: Microangiopathic ... hemolytic anemia ... Dehydrogenase #Elevated #differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Retroperitoneal, Uterine • Hemolysis ... : Autoimmune, Microangiopathic ... hemolytic anemia ... hematology #anemia #differential
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Schistocyte: Microangiopathic ... Hemolytic Anemia ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... RBC #Morphology #differential
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