12 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Hemolysis: • ... hemolytic anemia ... #Hemolytic #Intravascular ... #Causes #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Hemolysis - Differential ... and RES-mediated hemolysis ... - Hemolysis within ... immune-complex hemolytic ... malformations #Hemolysis
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Immune mediated hemolysis ... hemolytic anemia ... UnremarkableLab #Hemolytic ... #Anemia #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Schistocyte: Microangiopathic ... Hemolytic Anemia ... spherocytosis, Autoimmune hemolytic ... autoimmune hemolytic ... RBC #Morphology #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... anemiaCold ... • Compensated hemolysis ... hemolysis on rewarming ... #hemolytic #anemia
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Iron Deficiency Anemia ... - Differential ... Diagnosis Algorithm ... ) hemolysis, Intensive ... Structural: Celiac disease
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
for Hemolytic Anemia ... Causes: • Liver disease ... • AIHA: warm, cold ... udaygulati #Hemolytic ... #Anemia #Differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
bloodstream Hemolysis ... : • Hemolytic ... hemolytic anemia ... , PNH, immune hemolysis ... myelofibrosis • Hemolysis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Diagnosis Algorithm ... • Bleeding • Hemolysis ... Chronic Infection) High ... #Diagnosis #Algorithm