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diagnosis causes hematology anemia comparison hemolysis ophthalmology rheumatology aflp deficiency extravascular hellp hypomagnesemia inherited intravascular low magnesium management nephrology nutrition
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm ... Extrinsic RBC Defects ... Intrinsic RBC Defects ... : Membrane defects
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Abnormal Hgb & Hgb Defects ... Hgb - Membrane Defects ... - RBC Enzyme Defects
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... , Other enzyme defects ... Unstable hemoglobin defects ... Glutathione metabolism defects
Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... think of immune hemolysis ... #Classification ... Intrinsic #Extrinsic #Differential ... Diagnosis #Causes #Algorithm
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Intrinsic RBC Defects ... thalassemias), Membrane defects ... Extravascular #Causes #differential
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Membrane defects ... #Anemia #Differential ... Diagnosis #causes #classification
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
vessel vasculitis affects ... predominantly affects ... predominantly affects ... #Rheumatology #Differential ... Medium #Large #Classification
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Non-immune: Membrane Defects ... Spiders - Enzyme Defects ... - Hemoglobin Defects ... #Differential #
Isocoria - Pupillary Defects - Differential Diagnosis Algorithm Relative Afferent Pupil Defect • Optic Neuritis • Ischemic
Isocoria - Pupillary Defects ... - Differential ... Diagnosis Algorithm ... Pupillary #Pupils #Defects ... #Differential #
Causes of Hypomagnesemia - Differential Diagnosis Algorithm GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
Hypomagnesemia - Differential ... Diagnosis Algorithm ... Hypercalcemia-PTH effect ... ab • Genetics defects ... #Diagnosis #Algorithm
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