81 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... fraction < 20% Differential ... autoinflammatory diseases ... diagnosis #management #treatment ... #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Associated with more ... severe disease ... Associated with more ... Treatment: • Mild ... Summary #diagnosis #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease ... Thrombocytosis #Platelets #Differential
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... Puncture, EEG Treatment ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... disorders • Celiac disease ... effect following treatment ... Thrombocytosis #Differential ... Algorithm #Causes #Hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
lymphadenopathy more ... Responsive to Treatment ... Classification #pathophysiology ... #Hematology #Diagnosis ... #NonHodgkin #differential
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
and less common diseases ... diagnosis and treatment ... polychondritis • Behcet disease ... BEE #Syndromes #neurology ... #inflammatory #differential
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Lesions (75% or more ... skin injury) • Neurologic ... ) Differential Diagnosis ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
suspicion of severe disease ... bearing, limping for more ... splenomegaly, abnormal neurology ... - Sickle cell disease ... Rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology