16 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Pathway Activation (C3a ... and C5a) -> Anaphylatoxins ... Vasculitis #HUV #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... Phosphorus -> Ca-Phos ... urine pH) • Ca-Phos ... Syndrome #TLS #Pathophysiology
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Pool → ↑ HMG-CoA ... sequestration #pathophysiology
Magnesium Deficiency and Alcoholism

Risks associated with Mg deficiency in alcoholism:
 • Affects protein synthesis. energy production,
atherosclerotic CVS ... cardiomyopathy, sarcopenia, CVA ... Alcoholism #alcohol #pathophysiology
Vitamin D Metabolism
Fat-soluble vitamin
Sources: dermal synthesis and food (dairy products, fish)
Active form: calcitriol (1,25-OH Vitamin D)
Main
absorption of Ca ... endocrinology #pathophysiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
activation (↓ cAMP and Ca ... receptors, and Ca ... MOA: Block slow Ca ... channels to prevent Ca ... Classification #Classes #pathophysiology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... prevention (statin for CVA
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Plateau Phase • Ca ... leading to slow Ca ... receptors, and Ca ... MOA: Block slow Ca ... Classification #Classes #pathophysiology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome Pathophysiology ... Contraction → ↑ Renin ↑ Ca ... Gitelman #Syndrome #Pathophysiology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pharmacology and Pathophysiology ... increase. 2) The Na/Ca ... increase, the Na+2/Ca ... #Pharmacology #Pathophysiology