19 results
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Non-lmmune: • HELLP Syndrome ... HUS • DIC • Vasculitis ... #Algorithm #Causes ... #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Butterfly rash, Vasculitis ... Demyelinating syndromes ... #erythematosus ... signs #symptoms #diagnosis ... #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... : - Thrombocytopenia ... - Hemolytic anemia ... Kasabach-Merritt syndrome ... #hematology #rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... arteritis, Cogan's Syndrome ... (RA), Systemic lupus ... erythematosus ( ... #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... , Vasculitides, ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... Demyelinating Syndrome ... autoantibodies that will cause ... #SLE #CNS #neurology ... #rheumatology #
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... lymphopenia, low PLT • Anemia ... #Diagnosis #Rheumatology
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
Causes of Purpura ... SLE (systemic lupus ... erythematosus) ... infections - Vasculitis ... peds #pediatrics #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... Schistocytes, thrombocytopenia ... cardiac valve, vasculitis ... #Algorithm #workup ... #hematology #testing