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algorithm hemolytic workup atlas extravascular morphology oncology treatment agglutinin anemias antibody bandemia bloodcell calculation cbc classification coagulation cold common cvid
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... • Extrinsic RBC ... • Intrinsic RBC ... #Anemias #Differential ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Hemolysis - Differential ... elliptocytosis - RBC ... Differential #Diagnosis ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... • Intrinsic RBC ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Decreased WBCs ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Causes #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... ↑ LDH • Anti-RBC ... #Hemolytic #Anemia ... #diagnosis #management ... #treatment #rheumatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... Membrane): - Autoimmune ... 3) Internal (RBC ... Diagnosis #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... hemolytic anemia ... hemolytic anemia ... #Morphology #differential ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... , Disseminated intravascular ... coagulopathy (DIC) #RBC ... #differential # ... hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Anemia #Differential ... #workup #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... Diagnosis Framework ... Spherocytosis, G6PD, PK, HbC ... - Extrinsic: Autoimmune ... #Diagnosis #hematology
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