23 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... : • Autoimmune ... Hemolytic Anemias ... #Anemias #Differential ... #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Hemolytic Anemia ... 2) LOOK FOR a cause ... #Hemolytic #Anemia ... #diagnosis #management ... #treatment #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... intravascular coagulation ... #differential # ... diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... #Differential # ... #Causes #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... - Differential ... Diagnosis Algorithm ... anemia • ... #Causes #Hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... Diseases: • Systemic ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... Diagnosis Framework ... , CKD • Hemolytic ... - Extrinsic: Autoimmune ... #Diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... #Diagnosis #Causes ... #hematology #secondary
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
spherocytosis, Autoimmune ... hemolytic anemia ... hemolytic anemia ... #Morphology #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Membrane): - Autoimmune ... Defects: Sickle cell anemia ... Diagnosis #hematology