24 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential ... (AIHAs) • Alloimmune ... • Extrinsic RBC ... • Intrinsic RBC ... Diagnosis #Algorithm #hematology
An Approach to Jaundice Workup Algorithm by CBC and LFT Pattern

- Dr. Eric Strong @DrEricStrong

#Jaundice #Workup
Approach to Jaundice Workup ... Algorithm by CBC ... and LFT Pattern ... #Diagnosis #Hepatology ... #Differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... • Alloimmune ... elliptocytosis - RBC ... Extravascular #Differential ... Algorithm #Causes #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... ↑ LDH • Anti-RBC ... • Blood smear: Differential ... #diagnosis #management
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(AIHA) "Warm" ( ... (AIHA)"Cold" (usually ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
: CBC with diff, ... reticulocyte count, LFTs ... ↑ Destruction (hemolysis ... Diagnosis #Algorithm #hematology ... #workup
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... Membrane): - Autoimmune ... 3) Internal (RBC ... Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
hypertension • Unusual RBC ... acanthocytes - Consider RBC ... elliptocytosis, autoimmune ... Diagnosis #Algorithm #workup ... #hematology #testing
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Viral, Ischemia, AIH ... Ducts - PBC ... Burak @kwburak #LFTs ... Algorithm #diagnosis #hepatology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... spherocytosis, Autoimmune ... Agglutinate: Cold autoimmune ... #Morphology #differential ... #diagnosis #hematology